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The copper peptide research overview covers the full mechanism and the ~4,000 human genes documented as GHK-Cu-responsive in Broad Institute Connectivity Map analysis

Previous studies have shown that pyroptosis mediates a variety of downstream effects by activating caspase-1 through the canonical pathway or caspase-4/5/11 through the noncanonical pathway [9]

The antioxidant TEMPOL protects human hematopoietic stem cells from culture-mediated loss of functions

Glioma clumps formed by GBM lead to the upregulation of Piezo1 expression, which, in turn, promotes the rapid proliferation and invasion of glioma cells, accelerates the spreading range and speed of the clumps, and creates a vicious cycle (Velasco-Estevez et al., 2020), and changes in mechanical forces may lead to the activation of Piezo1 channels, exacerbating ischemic brain injury (Zhou et al., 2020)