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In contrast, 2 patients who developed ir-Myositis were re-challenged because of tumor progression, 1 with the same drug (avelumab) and the other with an alternative drug (ipilimumab/nivolumab replaced by pembrolizumab)

Rescue potential of P-PantSAc in HoPan treated mice In order to test the rescue potential of P-PantSAc in vivo in an established mammalian setting, we used HoPan-treated mice as previously described 34

Longer-term causes of zinc toxicity include occupational exposure to zinc [147] and iatrogenic causes such as overprescribing of zinc-containing medication, zinc present in dental fixtures (though modern preparations in the UK and US are now zinc-free) and overconsumption of over-the-counter zinc supplements [148]