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Exposure to these infectious pathogens and inflammatory stimuli can profoundly affect the brain and behavior ( Toxoplasma gondii infection, which, in animal models, alters behavior and increases the release of neurotransmitters such as dopamine, and the amount of dopamine release is correlated with the number of infected cells ( + T cells, which are crucial for sustaining lasting immunity, have been found to be downregulated in schizophrenia patients ( Toxoplasma gondii infection has been shown to affect the gut microbiome in mice ( Table 1 Clinical evidence for the association between infectious pathogens and schizophrenia