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In turn, the MAP3K phosphorylates a MAP2K, either MKK3 or MKK6, that then phosphorylates the TGY motif of p38 isoforms (Cuenda and Rousseau, 2007

2D-E, Supplementary Figure S3E-F)

The role of lipid-lowering as a target of natural drug action warrants further study of the relevant mechanisms between DKD and these two diseases and provides a potential research direction for the effective treatment of DKD