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In line with this, scientists at UCB demonstrated that the Fab of the anti-FcRn mAb rozanolixizumab could be expressed in a range of non-classical Ab formats with only one Fab, as opposed to the two found in classical bivalent IgGs, and retain the ability to shorten the plasma half-life of exogenously administered human IgG in human FcRn transgenic mice [124]

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Among these, NK cells express inhibitory receptors, such as cluster of differentiation (CD)94/NKG2-A/NKG2-B type II integral membrane protein (NKG2A) when binding MHC class I receptors

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