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MPTP activates ASK1-p38 MAPK signaling pathway through TNF-dependent Trx1 oxidation in Parkinsonism mouse model

Crucially, even metabolites with dual roles demand context: SCFAs induce protumor autophagy/chemokine signaling in prostate cancer (91), yet propionylcarnitine exhibits antitumor effects by suppressing Tregs and key chemokines such as CCL20 and CXCL8 (92)