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Pro-inflammatory adipokines (e.g., leptin, resistin) and adipose-derived exosomes (carrying miRNAs like miR-3074-5p) create a chronic inflammatory joint microenvironment by polarizing synovial macrophages toward an M1 phenotype and inhibiting anti-inflammatory adiponectin (1618)

For those unable to get enough B12 from their diet or oral supplements, injections offer a highly effective alternative

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Given this, we surmise the achievement of positive effects need the application of vitamin B12 in a larger population and with a longer treatment duration