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This deleterious process is initiated by the activation of CNS-resident microglia, which release an array of cytokines and chemokines, including C-C motif chemokine ligand 2 (CCL2) and C-X-C motif chemokine ligand 10 (CXCL10), that not only amplify local inflammatory responses but, more critically, alter BBB permeability through disruption of tight junction integrity (53, 54)

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J Pak Med Assoc:182184 Moore CA, Ward JC, Rivas ML, Magill HL, Whyte MP (1990) Infantile hypophosphatasia: autosomal recessive transmission to two related sibships

Carnitine is highly concentrated in the epididymis and plays a major role in sperm health (metabolism and maturation)