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Initially used to treat systemic iron overload, iron chelators have subsequently been found to exert neuroprotective effects and cross the bloodbrain barrier [174, 175]

The goal of a combination protocol is to keep tretinoin's proven resurfacing power while borrowing GHK-Cu's repair and barrier support to blunt irritation

These chemical reactions have been extensively characterized for a multitude of foreign chemicals, but they are also critical for the detoxification of endogenous reactive intermediates and, more importantly, for the formation of specific biological mediators (Wang and Ballatori, 1998)