increasing intracellular glutathione

increasing intracellular glutathione system enhancement for cardiac protection: pharmacological options against oxidative stress and ferroptosis Glutathione Metabolism - an overview

Name: increasing intracellular glutathione system enhancement for cardiac protection: pharmacological options against oxidative stress and ferroptosis Glutathione Metabolism - an overview
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Glutathione Metabolism an overview ScienceDirect Topics Glutathione: A Samsonian life sustaining small molecule that protects against oxidative stress, ageing and damaging inflammation PMC Apoptosis and glutathione: beyond an antioxidant Cell Death & Differentiation Glutathione: Master Antioxidant, Reducing Oxidative Stress, and Detoxification

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Immunologically GSH serves as a redox buffer, with GSH being the active form that upon neutralizing free radicals becomes converted into GSSG (Vairetti et al., 2021)

As predicted, when these two drugs were combined, the rifampicin-induced liver toxicity vanished, indicating that resveratrol acts on the liver cells (hepatocytes) protectively and neutralizes rifampicins toxicity, as we expected