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The exact cause of CFS/ME is unknown, but researchers have identified several potential contributing factors: Immune system abnormalities Impaired energy production in cells Brain abnormalities, such as changes in brain hormones or electrical activity Blood pressure and heart rate irregularities Genetic factors Infections or other illnesses, such as Epstein-Barr virus, Lyme disease, or Q fever Imbalances in brain chemicals, like serotonin, and hormones, like cortisol Diagnosing CFS/ME can be challenging, as there is no specific diagnostic test for the condition