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We then used native PAGE to determine if GDAP1TM could interact with products of lipid peroxidation, focusing on 4HNE and MDA, the two end-products formed by the decomposition of peroxidated lipids (Esterbauer et al., 1991)

To assess the effect of increasing ROS level on protein oxidation in double stress, the concentration of carbonyl groups in proteins was investigated (Fig

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Upon mPTP opening, cytochrome c (Cyt c) is released from the mitochondrial intermembrane space into the cytosol, initiating the intrinsic (mitochondrial) apoptotic pathway