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Attenuation of oxyradical chemistry

Drug-related resistance mechanisms include increased drug efflux via ABC transporters, decreased drug absorption caused by changes in lipid metabolism or drug carrier family member expression, and altered drug targeting

OxLDL also plays a pro-inflammatory role by stimulating endothelial cells to express adhesion molecules, such as vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) [71]

However, the immune response of the CNS is complex and involves a myriad of diverse cell populations such as astrocytes, microglia, macrophages, NK cells, and T and B cells (Aoyama, 2021)