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doi: 10.1093/ntr/ntv101 121

However, the Istituto Superiore di Sanit (ISS), the Italian public health institute that conducted the review on behalf of the Ministry of Health, concluded that there are 80 substances present either only in Iqos emissions or in much higher concentrations than in cigarettes

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It is worth noting that vaping products are themselves subject to a new UK tax regime that took effect in 2025, meaning this cost advantage may gradually compress over coming years as duty is applied to the vaping category as well