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Topical glutathione in the form of lotion is not efficiently absorbed by the skin cells as the thiol group undergoes rapid formation of disulfide.[] Also, apart from the poor permeability and absorption, foul odor limits its use

[17] The ratio of reduced glutathione to oxidized glutathione within cells is a measure of cellular oxidative stress [18] [11] where increased GSSG-to-GSH ratio is indicative of greater oxidative stress

Oxidative stress can lead to lipid peroxidation, a process in which ROS react with lipids in cell membranes, resulting in the formation of lipid peroxides and aldehydes such as malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE) [9]

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