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Abstract Pathogenic variants in one allele of the KAT6A gene encoding the histone acetyltransferase KAT6A (MOZ, MYST3) cause ArboledaTham syndrome (ARTHS), characterised by developmental delay, cognitive impairment, and autism-like behaviours

12 Other studies have now shown high levels of TMAO are associated with high levels of creatinine, low levels of HDL, type 2 diabetes and kidney disease 13

Sometimes, it is not easy to determine which alterations are due to old age and which are due to poor lifestyle or disease (pathological aging)