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If your refrigerator has a glass door or interior lights, store the vial in a small box or wrap it in foil

Gastrodin activates PI3K/AKT/mTOR signaling pathway in OLs Previous studies have demonstrated that the phosphatidylinositol 3-kinase (PI3K), adenosine 5-monophosphate (AMP)-activated protein kinase (AMPK), and Wnt signaling pathways are involved in regulation of myelination [41, 45]

Aliquot the reconstituted solution into single-use vials before freezing

SAEs relatedness to the administration of vitamin B 12 or placebo will be judged by the investigator/designee, the Ethics Committee and the DSMB who will have access to all relevant investigations, clinical assessments and if require unblinding allocated interventions