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As a biguanide antihyperglycemic agent, metformin works primarily by decreasing hepatic glucose production, reducing intestinal glucose absorption, and improving insulin sensitivity in peripheral tissues

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The second batch consisted of AAVs experiments (Hcy+AAV-Vector, Hcy+AAV-Ndufa1, and Con groups)

Excess folate in the presence of low Vitamin B12 levels can lead to problems however the B12 deficiency is effectively masked by the action of folate which will apparently resolve the megaloblastic anaemia caused by deficiency of either vitamin, but will not resolve the effects of B12 lack