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Thereafter, brain and hippocampus were collected for oxidative and neurochemical analysis

Yaikwawong and colleagues (Yaikwawong et al., 2025) reported in a 12-month randomized controlled trial in 78 patients with T2D and MASLD that 1,500 mg/day curcumin significantly reduced TNF-, IL-1, IL-6, and malondialdehyde levels at all follow-up intervals (3, 6, 9, and 12 months) while increasing antioxidant enzyme activities (glutathione peroxidase, superoxide dismutase) and significantly improving hepatic steatosis and liver stiffness measured by FibroScan

It supports the production of acetylcholine in the brain and also appears to bind directly to acetylcholine receptors

Injection site rotation reduces localized irritation across repeated application cycles