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Poor Blood Circulation Reduced circulation, often due to stress, lack of sleep, or smoking, can limit oxygen and nutrient supply to the skin, making it appear tired and lacklustre

Accumulation of advanced glycation end products (AGEs) resulting from aberrant glycation reactions plays a pivotal role in both DM progression and its associated complications (Khalid et al., 2022)

In fact, another studys results supported the finding diminishing glutathione levels is one of the events that eventually leads to oxidative stress and the development of immunological intolerance in Hashimotos patients

These components possess varied permeability to different substances, which contributes to the selective transport of molecules into the brain []