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doi:10.1056/NEJMoa1916433

The paper states that, while the tobacco industry claims a 90-95% reduction in harmful and potentially harmful substances and toxicity for heated tobacco products, this is not the full picture

"They tend to usually be in controlled substances." The markup on wine was passed as part of a larger measure that will for the first time allow wine to be sold in supermarkets and convenience stores in dozens of cities and counties that approved the practice in referendums in November

Another drawback of case control studies is that the exposure measure (cannabis use) has to be assessed retrospectively