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Indeed, the HF-AF ENERGY trial aims to assess whether nicotinamide riboside, an NAD+ precursor shown to be safe and to boost NAD+ levels in humans, can normalize blood-based markers of mitochondrial function and the NAD metabolome and, crucially, AF burden in the context of ischemic cardiomyopathy [98,99]

doi: 10.1111/bju.14192 97 CirilloGSpizzirriUGCurcioMNicolettaFPIemmaF

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