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Description

Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway

What About Side Effects and Before-and-After Claims

Ovarian cells were found to secrete significant levels of VEGF, a direct activator of angiogenesis, but squalamine did not reduce VEGF secretion by tumor cells, and it evoked no direct growth inhibition of ovarian cells in vitro [69]