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Yet another mechanism contributing to the specific vulnerability of the gastrointestinal system to TD may involve the gut-brain axis, which depends on vagal tone and acetylcholine neurotransmission, for which thiamine co-release is known (165167)

For example, the mechanosensitive ion channel Piezo1 is markedly upregulated in the colonic mucosa of patients with UC (Zhou et al., 2025a), and its excessive activation exacerbates epithelial injury, in part by promoting ferroptosis (He H