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This uses S-adenosylmethionine (SAM) as a methyl donorwhich DNA and protein methylation also need3

As a result, malignant cells need to control the concentration of H 2 O 2 precisely to avoid excessive oxidative damage, while enabling the pro-tumorigenic effects of H 2 O 2 signaling

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CD38, a transmembrane glycoprotein that lacks an internal signaling domain, is a surface molecule expressed by normal T, B, NK and myeloid populations as well as by different tumor cells ( + levels inside the BM niche where the mPC grows (40)