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Although alterations in genetic factors have been linked with its etiology, exponential accumulation of environmental entities such as reactive oxygen species (ROS) initiate a cyclic chain reaction resulting in accumulation of cellular inclusions, dysfunctional mitochondria, and overwhelming of antioxidant machinery, thus accelerating disease pathogenesis

Importantly, IgG NOAbs to senescent erythrocytes are often directed against their most abundant integral membrane protein, the anion-transport protein, also known as AE1 [220]

Southern Thoracic Surgical Association 2009 56th Annual Meeting:70, 2009