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Liu et al., 2025)

Platelet activation in patients with sickle disease, hemolysis-associated pulmonary hypertension, and nitric oxide scavenging by cell-free hemoglobin

These effects occur partly through estrogen receptor activity in the hypothalamus and partly through alterations in lipid metabolism

In PD, aggregated syn, particularly in its protofibrillar form, impairs proteasome activity, reducing its efficiency in processing both ubiquitinated and nonubiquitinated substrates [166, 167, 168]