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In combination with a halved rate of cell division, this indicates that defects in FXN/YFH1 alters iron metabolism and/or intracellular accumulation

After administration of PTER and RES at the same dose to male and female mice for 8 weeks, PTER reached higher concentrations in the serum and in the brain than RES ( The high lipophilicity of PTER allows it to easily cross the blood-brain barrier (Temsamani et al., 2015), resulting in greater neuroprotection than RES (Kutil et al., 2015), decreasing the levels of lipid and protein oxidation (Czpaski et al., 2012)

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Carley AN, Severson DL