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Overview of proteasome inhibitor-based anti-cancer therapies: perspective on bortezomib and second generation proteasome inhibitors versus future generation inhibitors of ubiquitin-proteasome system

This review discusses the underlying molecular mechanisms of COVID-19 infection accompanied by CNS invasive pathway(s) and/or associated CNS complications, and what NT can add, in the following three aspects: (i) we will list proteins/receptors/enzymes that are responsible for CoV-2 entry to CNS and also list consequences after that entry from neuroinflammation to neurological manifestations via the bloodbrain barrier (BBB) disruption mechanisms

Isgs such as Isg15, interferon alpha inducible protein (Ifi)27l2a, interferon-induced protein with tetratricopeptide repeats (Ifit)1, Ifit2 and Ifit3 were increased, and Isg20, interferon induced transmembrane protein (Ifitm)1, Ifitm2, Ifitm3 were decreased in the CD8 + T cells of high glucose drink group

Cell Mol Life Sci 80(11):342