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The above findings showed that the body-weight effect of the conjugate can partially be governed by actions in adipose depots because glucagon receptors exist in rodent adipocytes, less than in liver

In drug-induced pyridoxine deficiency, such as in patients taking isoniazid, a higher replacement dose is often used, for example, 100 mg IV or IM daily for 3 weeks, to rapidly correct the deficiency, followed by a maintenance dose of around 30 mg daily