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The number of polarized M1 macrophages peaks at one week after injury and exacerbates neuroinflammation by secreting inflammatory cytokines such as TNF- and IL-6 (Ko et al , 2017)

Tissue injury raises serum CRP levels, which are mostly controlled by IL-6

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urinaria , triggers HepG2 cell apoptosis via the endoplasmic reticulum stress/CHOP pathway