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Beyond the uPA system, TF itself has emerged as a potent and specific therapeutic target, and this is because of it being the primary initiator of the extrinsic coagulation cascade, as well as being aberrantly expressed on a variety of cancer cells and on tumor-associated endothelium, where it contributes to multiple hallmarks of cancer, including sustained proliferation, evasion of cell death, angiogenesis, and activation of invasion and metastasis

Effects of acupuncture on microglial polarization and the TLR4/TRIF/MyD88 pathway in a rat model of traumatic brain injury

This route avoids digestive degradation and first-pass liver metabolism

doi: 10.1182/blood-2021-152985