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Since lower airway cells express low levels of ACE2 and are difficult to infect directly in culture, accumulation of SARS-CoV-2 in the upper airway may be needed before the virus can achieve infection of the lower tract

This mandates a cautious approach, especially for those with pre-existing conditions

To reduce the number of false-positives, crosslinks identified using XLinkX were filtered for an identification score 20

Collectively, this raises the notion that the observed differences here are perhaps related to long-term selenium intake, a micronutrient that has been speculated to play a role in konzo pathogenesis, due to its essential requirement for maintaining antioxidant machinery 18