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Given the potential impact of ferroptosis on the tumor microenvironment, the trial protocol would mandate rigorous monitoring for myelosuppression and immune-related adverse events

To verify the proposed mechanism of action of NMN, we studied longterm NMN supplementation and its impact on ovarian health and discovered that NMN helps prevent ovarian atrophy

Mechanistically, JUH083 decreased immunosuppressive cells such as monocytes and myeloid-derived suppressor cells, regulatory T cells, pro-tumorigenic CD4 + Th17 cells, and boosted the infiltration of CD8 + T cells and CD4 + Th1 cells