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And, they reverse the hypermethylation of CpG islands in the promoter region of tumor suppressor gene by upregulating genes that are methylated due to fibrosis, such as the RASAL1 gene ( However, the disadvantages of 5AC and DAC are becoming increasingly apparent

While such durations are commonly used to assess direct cellular responses, they do not fully recapitulate the chronic or long-term exposures experienced in real-life settings