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Following its physiological action, 1,25(OH)D is further catabolized by CYP24A1 into final metabolites such as calcitroic acid and 1,25(OH)D26,23 lactone, which are subsequently excreted in bile or urine [96, 102].(Fig

Additionally, IS levels are influenced by dietary protein intake (particularly aromatic amino acids), gut transit time, and medications (phosphate binders, antibiotics)