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Studies have shown that liposomes modified with the transferrin receptor antibody OX26 can activate receptor-mediated transcytosis, significantly improving the ability of drugs to cross the bloodbrain barrier, thereby achieving sustained therapeutic effects in PD rat models (Xia et al., 2008)

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References Arruda LS, Rodrigues A, Bermudez N, Ribeiro L, Siqueira H (2020) Field resistance of Plutella xylostella (Lepidoptera: Plutellidae) to lufenuron: inheritance and lack of cross-resistance to methoxyfenozide

Interestingly, the activity of methylating enzymes such as the S -adenosylmethionine-dependent protein arginine methyltransferase (type I) 103 responsible for the ADMA synthesis or the activity of ADMA hydrolyzing enzymes such as dimethylarginine dimethylaminohydrolase 102 are redox sensitive