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They establish biological mechanisms in controlled settings but do not constitute proof of specific human outcomes

[26] On the other hand, presence of ALDH2*2 in East Asians (a variant of the ALDH gene), can cause blood acetaldehyde levels of 30 to 75 M or higher, which is more than 10 times the normal level

Para que uma substncia seja usada por via oral ou injetvel em humanos, so necessrios estudos que avaliem absoro, distribuio, metabolismo, excreo, toxicidade, dose, segurana em populaes especficas, interaes, eventos adversos e eficcia em desfechos clnicos

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