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The majority of the mutations causing severe MTHFR deficiency are reported in the catalytic domain (Figure 2B)

On l'utilise donc dans le traitement curatif de l' anmie par carence en fer chez l'adulte, l'enfant et le nourrisson partir de 1 mois, ou en traitement prventif ou curatif de la carence en fer chez la femme enceinte, le nourrisson et l'enfant lorsqu'un apport alimentaire en fer est insuffisant

Through binding key domains involved in host cell attachment and membrane fusion, these CQDs effectively disrupted early-stage viral infection, resulting in a marked reduction in viral entry and replication, suggesting that surface functionalisation can confer targeted disruption of viral-host interactions [130]