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Improved joint function can reduce pain, allow for better movement patterns, and lower the risk of falls, which is a major concern for people with neuropathy (Pollock et al., 2022)

The 3A mutation in GAP-F5 protein effectively blocks the increase in G2019S LRRK2-mediated phosphorylation in response to increasing amounts of GAP-F5 protein substrate, compared to the concentration-dependent increase in WT GAP-F5 phosphorylation, by in vitro radioactive kinase assay ( Fig