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Both pathways cleave gasdermin D (GSDMD), a member of the Gasdermin family, to release its gasdermin-N domain, which penetrates the plasma membrane to induce cell swelling and osmotic lysis

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[DOI] [PubMed] [Google Scholar] 87.Yang Y, Iji PA, Choct M

Lactation: Advise women not to breastfeed during treatment with Pemetrexed Injection and for 1 week after the last dose [see Use in Specific Populations (8.2)]