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Interestingly, glutamate also exert important modulatory effects on EECs, sending sensory signals to the vagus nerve [173] GABA is biosynthesized from glutamate due to the action of the enzyme glutamate decarboxylase, which is found in eukaryotic cells and in a broad spectrum of bacterial species [174]

The progression of diabetic nephropathy is multifaceted, influenced by factors such as renal hemodynamic abnormalities, dyslipidemia, oxidative stress, and hormone synthesis, including Angiotensin II (Ang II)

PMC 9710288

The disease is characterized by severe gastrointestinal dysmotility, sensorimotor peripheral neuropathy, severe muscle weakness, and progressive leukoencephalopathy, with patients usually dying from a combination of nutritional failure and muscular disability