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Conclusion: NAFLD patients with high soluble TREM2 serum levels might be at increased risk of disease progression, and potentially benefit from a closer surveillance

The most common neurodegenerative diseases, such as Alzheimers (AD), Huntingtons (HD) and PD, are all marked by the accumulation of misfolded proteins, which play a crucial role in the dysfunction or loss of neurons through their deposition within cells or the extracellular matrix (Singh et al., 2019)