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Toxics 11 , 40 (2022)

Medical conditions that can lead to a B12 deficiency include: Inflammatory bowel disease (IBD) Lymphoma Exocrine pancreatic insufficiency (EPI) Small intestinal bacterial overgrowth (SIBO) Chronic pancreatitis Protein-losing enteropathy (PLE) Gastrointestinal worms Liver disease Kidney disease Gastrointestinal cancer Hereditary cobalamin deficiency and low levels of dietary cobalamin are rare causes of cobalamin deficiency

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In one of the most promising preclinical studies , Dihexa restored cognitive performance in a rat model of Alzheimers disease , outperforming donepezil (Aricept), a common Alzheimers drug