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Cholinergic modulation of nociceptive responses in vivo and neuropeptide release in vitro at the level of the primary sensory neuron

His MR spectra with shorter echo time (TE) (35 ms) revealed decreased N-acetylaspartate /creatine (NAA/Cr) ratios in white and gray matter, as well as increased choline and myo-inositol-to-creatine ratios in white matter, among others

279 Because LRRK2 mutations are a common cause of familial Parkinsons disease and increase the risk of sporadic Parkinsons disease, 280,281 LRRK2 inhibitors with actions such as those seen with adenosylcobalamin are being investigated as possible therapeutic agents for Parkinsons disease

By producing the Met through its metabolite betaine, choline also aids in the Met cycle (86)