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However, it does not correct the underlying cystic fibrosis transmembrane conductance regulator defect, as shown by the lack of improvement in nasal transepithelial potential difference in cystic fibrosis transmembrane conductance regulator-deficient mice, indicating that epithelial ion transport remains impaired

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The reason of such inconsistency is that the algorithm does not recognize the difference between cysteine and cystine and does not take the effect of S-S bridges on secondary structure under consideration