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This selectivity profile is what distinguishes FOXO4-DRI from broader cytotoxic agents and makes it the primary peptide tool for selective senescent cell elimination in the cellular senescence research field

Repeated impingement and mechanical stress can cause collagen fibrils to undergo deformation, affecting their alignment and cross-linking patterns

Its anti-inflammatory effects limit immune-mediated tissue damage, while angiogenesis improves blood flow, delivering oxygen and nutrients to injured areas to accelerate healing

The organic layer was dried over anhydrous NaSO, filtered, and concentrated under reduced pressure to obtain Compound 6 (yield: 85%)