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High doses of uremic toxin inhibit the activity of the cdc2-cyclin B1 complex through phosphorylation, block the progression of myoblasts in the G2/M phase, and induce their apoptosis, resulting in stunted skeletal muscle cell proliferation (69)

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Severe coronary artery stenosis can lead to IRI after recanalization, HF after myocardial injury, and even ischemic cardiomyopathy (Zhaolin et al., 2019)