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Moreover, local application of the GABAA receptor modulator midazolam to the cochlea reversed salicylate-induced increases in cochlear BDNF expression while concurrently reducing tinnitus perception in the animal model, accompanied by restoration of cortical Arg3.1 expression, revealing a functional BDNF-mediated cochlearcortical axis in tinnitus pathophysiology (Panford-Walsh et al., 2008)

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Elevated CSF IL-6 in a group of suicidal mood-disordered patients that included several bipolar subjects correlated with more rapid 5HT and dopamine turnover, as evidenced by increased levels of their metabolites (214)

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