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Previous studies have demonstrated that rapamycin, an inhibitor of mTOR, reduces GPX4 protein expression and promotes ferroptosis and autophagy 9,10

While this hypothesis sheds light on some of the confusing results that have been reported in simpler model membranes, it needs to be confirmed in other biological membranes

Mitochondria represent attractive targets for phototoxic agents due to their susceptibility to oxidative stress and their crucial roles in regulating intracellular Ca 2+ levels, oxidative stress, survival/apoptotic signaling pathway, cellular differentiation and the cell cycle 98

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